Anti-Aging Glutathione

The use of supplemental glutathione for anti-aging has sparked controversy in the medical community, with some researchers calling it a powerful health restorative and others saying there's just not enough evidence to justify those claims.

Glutathione (also sometimes known as GHS) is a natural compound. It is found in some foods, including many fruits, vegetables, and meats, and it can also be synthesized within the body, from three amino acids (L-cysteine, L-glutamic acid, and glycin).

Glutathione is known to be a powerful antioxidant
, effective at protecting cells from free radicals (unstable molecules formed during the process of cellular oxidation). It's active in human lungs and in many other organ systems and tissues, and plays an active role in maintaining the immune system.

Though glutathione was first isolated eighty years ago, it's metabolism within the body has only been understood since 1984. Studies and clinical trials of glutathione in the treatment of cancer, ALS, cystic fribrosis, and asthma are currently taking place, but though studies on its potential health benefits are ongoing, a relatively limited body of research is currently available.

Antioxidant = Anti-Aging?
Glutathione's potent antioxidant properties give it what appears to be enormous potential as an anti-aging supplement, because many of the health problems associated with free radical damage. Antioxidants can neutralize free radicals, preventing and even repairing the damage they do.

Preliminary research has shown a correlation between high glutathione levels and good health in older adults
, but while initial results seem promising most studies on the substance have been small and limited.

Questions About Best Method of Supplementation
One of the primary questions about glutathione is whether oral supplements are effective. Some studies have indicated that giving patients oral supplements of as much as 3000 IU resulted in no increase in blood levels of glutathione, while other research showed that taking other nutritional compounds did effectively raise blood levels of glutathione. In one trial, supplementation of vitamin C raised glutathione blood levels by almost 50%. The study concluded that vitamin C raises glutathione levels by helping the body produce it.

But though questions persist about the extent to which oral glutathione can be absorbed, small studies using other methods of supplementation have produced exciting results. Glutathione administered intravenously or intramuscularly has been found useful for preventing clot formation during operations, treating Parkinson's disease, reducing high blood pressure in diabetics, and increasing the effectiveness of certain chemotherapy drugs.

Source: EasyArticles | RAB

The Problem With Glutathione As An Anti-Aging Supplement

In simple terms What is Glutathione?

Glutathione is a naturally occurring antioxidant that exists in every cell in the human body including the skin.  It is said to be the world's most powerful antioxidant.  While it does occur naturally, over time the natural production of glutathione declines with age and that deficiency causes age-related diseases.

How does Glutathione benefit me?
       
Glutathione is the human body's most abundant, natural antioxidant. Glutathione protects your vision, strengthens the immune system, aids in turning carbohydrates into energy, and prevents the accumulation of oxidized fats that may contribute to atherosclerosis.

The Glutathione in your skin helps protect your skin from sunburn and wrinkling.  There is an old saying that goes like this: "As your skin goes, so goes the rest of your body".
Glutathione  may help offset the physical effects and problems of aging. Adequate levels of glutathione are needed to help the immune system fight off free-radical damage, infection, and illness. Glutathione can prevent or diminish symptoms of conditions like asthma and rheumatoid arthritis.

What are the results of Glutatione deficiency?

Glutathione deficiency is a leading cause of  oxidative damage in the human body, which plays an important role in aging and the devastating effects of many diseases including Alzheimers, Parkinsons, liver disease, cystic fibrosis, sickle cell anemia, HIV, AIDS, cancer, heart attack, and diabetes.  A Glutathione deficiency can have a debilitating effect on the nervous system, causing problems such as lack of balance and coordination, mental disorders, and tremors. Any illness such as the flu or even a bad cold, chronic conditions like asthma and rheumatoid arthritis, simple injuries, or heavy exposure to pollutants can cause a Glutathione deficiency. This is because your body uses more Glutathione when it is producing white blood cells and attempting to rid the body of toxins.

Can I get enough Glutathione in my diet?

Glutathione is found in almost all fruits and vegetables. Winter (yellow) squash, asparagus, avocados, cantaloupes, grapefruits, okra, oranges, peaches, potatoes, spinach, strawberries, tomatoes, and zucchini are all good sources of GSH. Some vegetables, such as broccoli, cabbage, Brussels sprouts, cauliflower, and kale, not only provide the body with Glutatione, but also actually stimulate the body's production of more of this amazing antioxidant. Cooking destroys a lot of the glutathione in fresh fruits and vegetables.  In order to get the most Glutatione from these foods is by eating them raw or steamed. Foods high in glutamine, such as lean meats, eggs, wheat germ, whey protein and whole grains, can also stimulate the liver to produce more Glutathione naturally.

How effective are naturally occurring forms of Glutathione?

Although Glutathione is found naturally in many fruits, vegetables, and meats, absorption rates of glutathione from food sources in the human gastrointestinal tract are low.

Can I take a Glutathione supplement?

Although glutathione is marketed as a nutritional supplement, there is no evidence that most Glutathione supplements actually increase the levels of Glutathione in the cells. However oral supplements of whey protein do appear to aid in the restoration of cellular levels of Glutathione.
Glutathione is also included in many multivitamin and multi-nutrient formulations, however their effectiveness come into question.

Are there any side effects of supplementing with Glutathione?

There is no Recommended Dietary Allowance (RDA) for Glutathione, but supplements have no known harmful side effects. Glutathione supplements can be expensive, but there is some question about the body's ability to absorb most supplements efficiently.
There appear to be no risks associated with Glutathione supplementation, even using up to several grams a day.

What are the precautions?

At this time, the only established precautions are sensitivity to any of the inactive ingredients in the various preparations of Glutathione or the products used to stimulate Glutathione levels. There are some studies that suggests supplementing it may be helpful to some cancer patients.

Conclusion

Increased levels of Glutathione (GSH) strengthen your immune system, increase your energy level, and enhance the body's fight against aging and the ailments of aging. Increased levels of GSH also result in a faster recovery from strenuous exercise regimens.

Your enhanced immune system will make you less susceptible to illness and the effects and multiple ailments of aging. You will also experience a higher level of alertness and experience a more rapid recovery from strenuous exercise with shorter periods of soreness.

Source:  SearchWarp - Merrill Noreen

The Delicious Path Of Antiaging Nutrition

Plant nutrients play a key role in anti aging. Fruit, vegetables, and plant extracts have an array of chemical constituents, called phytochemicals or phytonutrients, that are hugely beneficial to skin health and beauty.

In plants, phytochemicals confer characteristics like color, which can help the plant by providing an attractive beacon to passing bees to help in pollination. Or they offer a protective effect to the plant to prevent insects from harming it, or repel grazing animals. But they have often been found to have benefits for human health when analyzed in laboratories. It is these chemicals in plants that make fruit and vegetables so much more valuable than simply the macro nutrients like vitamin C.

Antioxidants are one class of phytonutrients, though there are many. Antioxidants work by supplying an extra oxygen molecule to those molecules that are missing one, called free radicals. If antioxidants don't supply the missing oxygen molecule to free radicals, the free radicals will take an oxygen molecule from another compound in the body, making one that was previously healthy and intact itself a free radical. Free radicals are not 'baddies', simply unstable chemical molecules, but the effect they have on the body is negative, as they can damage cells. Free radicals are produced as a normal by product of the metabolic processes of our cells, as well as by our immune system as it counteracts the effects of pathogens and the environment.

The trick is to keep the balance in the body where there is enough of a supply of antioxidants to cope with the body's production of free radicals.

Free radicals affect the skin in three main ways. They can alter the fatty layers in your cellular membranes. These fatty layers provide structure to the cell, and control which nutrients and other agents can pass in and out. They can alter the DNA within cells, which aside from the potential to develop into serious illnesses, can make your skin inclined to wrinkles and sagging before its natural biological time. Altered DNA creates a blueprint for collagen and elastin fibers that don't function as healthy, normal ones would. And to compound matters, the skin's pores need healthy collagen and elastin fibers to stay tight and small. So another undesired result is open, large pores.

Free radicals also lead to a process called the cross-linking of collagen fibers. This occurs in the skin's dermis, as a result of collagen and elastin fibers becoming hard, thick, and then binding together. Cross-linked fibers create wrinkles, skin sag, and cause your regular expression lines to become etched in your face as a permanent fixture. With healthy collagen and elastin fibers these expression lines would simply disappear once you moved your facial muscles in a different way. And enzymes that metabolize collagen are encouraged by free radicals, which, given the importance of collagen in youthful looking skin, is best minimized.

Other phytonutrients in plants that are of importance to skin beauty are carotenoids and flavanoids. Flavanoids are great for the health of blood vessels. They strengthen the capillaries that supply important nutrients to the skin's cells, as well as supporting cellular membranes. Healthy cell membranes regenerate quickly, and slow the aging process. Carotenoids also strengthen cell membranes. It seems carrots are not just good for eyesight! And flavanoids help reduce inflammation, as well as increasing levels of glutathione, which is an antioxidant.

Source: EasyArticle